New insights into the pathophysiology of lymphedema are providing targets for future treatment interventions to cure and prevent the disease, according to our recent research.

Previously, it was believed that the lymphatic vasculature played a passive role by transporting antigen-presenting cells and soluble antigens to regional lymph nodes. However, the most recent studies show that lymphatic endothelial cells regulate immune responses more directly. They control the entry of immune cells into lymphatic capillaries, present antigens on major histocompatibility complex proteins, and modulate antigen-presenting cells.

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Oncologic outcomes are similar with the use of a sentinel lymph node (SLN) algorithm compared to performing a full pelvic and paraaortic lymph node dissection (LND) in node-negative patients with deeply invasive endometroid endometrial carcinoma (EEC), according to our recent research, the first to compare these two assessment methods in this patient population.

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Studying mutational changes that occur in brain tumors has been difficult. A new approach involves analyzing cancer DNA that the tumor sheds into the fluid surrounding the brain and spinal cord. This fluid can be collected in biopsies to help with diagnosis and choosing treatment.

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