New insights into the pathophysiology of lymphedema are providing targets for future treatment interventions to cure and prevent the disease, according to our recent research.

Previously, it was believed that the lymphatic vasculature played a passive role by transporting antigen-presenting cells and soluble antigens to regional lymph nodes. However, the most recent studies show that lymphatic endothelial cells regulate immune responses more directly. They control the entry of immune cells into lymphatic capillaries, present antigens on major histocompatibility complex proteins, and modulate antigen-presenting cells.

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Temozolomide chemotherapy reduced seizures in 90 percent of patients with World Health Organization (WHO) grade 2 oligodendroglioma and tumor-related epilepsy, according to the results of a recent retrospective study of 39 patients treated at Memorial Sloan Kettering Cancer Center.

Our study, published in the journal Neuro-Oncology Practice, is the first to examine seizure response to temozolomide in a homologous group of adult patients with oligodendroglioma, the glioma subtype that has the highest frequency of seizures.

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Oncologic outcomes are similar with the use of a sentinel lymph node (SLN) algorithm compared to performing a full pelvic and paraaortic lymph node dissection (LND) in node-negative patients with deeply invasive endometroid endometrial carcinoma (EEC), according to our recent research, the first to compare these two assessment methods in this patient population.

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