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On Cancer - May 24, 2017
Mirror-Image Chemistry Enables New Approach for Targeting an “Undruggable” Cancer-Causing Protein

Drug development is a complicated task. In the era of targeted therapies for cancer, medicinal chemists seek to design drugs that selectively block the activity of proteins driving tumor growth. But molecules that block these cancer-causing proteins don’t always make effective drugs. Now, for one such protein, called KRas, a collaborative team from Memorial Sloan Kettering and Harvard University is reporting the first step of an approach to make targeted drugs that are more effective.

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